منابع مشابه
Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition
BACKGROUND It remains controversial whether hormone therapy in recently postmenopausal women modifies the risk of Alzheimer's disease (AD). OBJECTIVE To investigate the effects of hormone therapy on amyloid-β deposition in recently postmenopausal women. METHODS Participants within 5-36 months past menopause in the Kronos Early Estrogen Prevention Study, a randomized, double blinded placebo-...
متن کاملAssociation of lifetime cognitive engagement and low β-amyloid deposition.
OBJECTIVE To assess the association between lifestyle practices (cognitive and physical activity) and β-amyloid deposition, measured with positron emission tomography using carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB), in healthy older individuals. DESIGN Cross-sectional clinical study. SETTING Berkeley, California. PARTICIPANTS Volunteer sample of 65 healthy older individuals (me...
متن کاملprocessing and β - amyloid deposition in sporadic Creutzfeldt - Jakob patients
1) Molecular and Cellular Neurobiotechnology, Institute of Bioengineering of Catalonia and Department of Cell Biology, University of Barcelona, Baldiri Reixac 15-21, 08028 Barcelona, Spain. 2) Institute of Neuropathology (INP), IDIBELL-Hospital Universitari de Bellvitge, Faculty of Medicine, University of Barcelona, 08907 Hospitalet de LLobregat, Spain. 3) Centro de Investigación Biomédica en R...
متن کاملLongitudinal patterns of β-amyloid deposition in nondemented older adults.
BACKGROUND High levels of β-amyloid (Aβ) characterize Alzheimer disease. OBJECTIVE To investigate whether longitudinal changes in Aβ deposition can be detected in vivo in older adults without dementia (hereafter referred to as nondemented). DESIGN Prospective study. SETTING Community-dwelling older adults. PARTICIPANTS Twenty-four nondemented participants (4 with a baseline Clinical Dem...
متن کاملCX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.
In Alzheimer's disease (AD), amyloid-β (Aβ) deposits are frequently surrounded by activated microglia but the precise role of these cells in disease progression remains unclear. The chemokine receptor CX3CR1 is selectively expressed in microglia and is thought to modulate their activity. To study the specific effects of microglia activation on amyloid pathology in vivo, we crossbred mice lackin...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2011
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3059